Search results for "ácidos pipecólicos"

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Lysine pathway metabolites and the risk of type 2 diabetes and cardiovascular disease in the PREDIMED study: results from two case-cohort studies

2019

[Background]: The pandemic of cardiovascular disease (CVD) and type 2 diabetes (T2D) requires the identification of new predictor biomarkers. Biomarkers potentially modifiable with lifestyle changes deserve a special interest. Our aims were to analyze: (a) The associations of lysine, 2-aminoadipic acid (2-AAA) or pipecolic acid with the risk of T2D or CVD in the PREDIMED trial; (b) the effect of the dietary intervention on 1-year changes in these metabolites, and (c) whether the Mediterranean diet (MedDiet) interventions can modify the effects of these metabolites on CVD or T2D risk. [Methods]: Two unstratified case-cohort studies nested within the PREDIMED trial were used. For CVD analyses…

Malelcsh:Diseases of the circulatory (Cardiovascular) systemTime FactorsMediterranean dietEndocrinology Diabetes and MetabolismhumanosDiseaseType 2 diabetes030204 cardiovascular system & hematologyDiet Mediterraneanchemistry.chemical_compound0302 clinical medicineRisk Factorsestudios prospectivosevaluación de riesgosMetabolites030212 general & internal medicineProspective Studiesmediana edadOriginal InvestigationPipecolic acidRandomized Controlled Trials as TopicAged 80 and overancianodietaácidos pipecólicosensayos clínicos controlados aleatorizados como asuntoresultado del tratamientoIncidenceType 2 diabetesMiddle AgedCardiovascular disease3. Good healthPrimary PreventionTreatment OutcomeCardiovascular DiseasesPipecolic AcidsFemaleCardiology and Cardiovascular Medicineconducta de reducción del riesgoCohort studymedicine.medical_specialtyenfermedades cardiovascularesácido 2-aminoadípicoRisk Assessmentincidencia03 medical and health sciencesfactores de tiempoInternal medicineDiabetes mellitusmedicineDiabetes Mellitusfactores de riesgoHumansAngiologyAgedProportional hazards modelbusiness.industryLysinemedicine.diseaseDietlisinaDietary interventionchemistryDiabetes Mellitus Type 2lcsh:RC666-701business2-Aminoadipic AcidRisk Reduction BehaviorBiomarkers
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